Better Bones References

Product references — Alpha-lipoic acid

Hah, Y., et al. 2007. Dietary alpha lipoic acid supplementation prevents synovial inflammation and bone destruction in collagen-induced arthritic mice. Rheumatol Int. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20496068 (accessed 06.30.2010).

Lee, E., et al. 2007. Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice. Rheumatol. Int., 27 (3), 225–233. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16944157 (accessed 06.30.2010).

Ghibu, S., et al. 2009. Antioxidant properties of alpha-lipoic acid: Effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia. Mol. Cell Biochem., 320 (1–2), 141–148. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18839280 (accessed 12.18.2008).

Amom, Z., et al. 2008. Lipid lowering effect of antioxidant alpha-lipoic acid in experimental atherosclerosis. J. Clin. Biochem. Nutr., 43 (2), 88–94. URL (abstract): http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18818758 (accessed 12.18.2008).

Bagh, M., et al. 2008. Dietary supplementation with N-acetylcysteine, alpha-tocopherol and alpha-lipoic acid prevents age-related decline in Na(+), K(+)-ATPase activity and associated peroxidative damage in rat brain synaptosomes. Biogerontology, 9 (6), 421–428. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18787974 (accessed 12.18.2008).

Biewenga, G., et al. 1997. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol., 29 (3), 315–331. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9378235 (accessed 12.18.2008).

Bist, R., & Bhatt, D. 2008. The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane. J. Neurol. Sci. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18950802 (accessed 12.18.2008).

Chae, C., et al. 2008. The combination of alpha-lipoic acid supplementation and aerobic exercise inhibits lipid peroxidation in rat skeletal muscles. Nutr. Res., 28 (6), 399–405. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19083438 (accessed 12.18.2008).

Elangovan, S., & Hsieh, T. 2008. Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells. Int. J. Oncol., 33 (4), 833–838. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18813798 (accessed 12.18.2008).

Ghibu, S., et al. 2008. [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases.] Ann. Cardiol. Angeiol. (Paris), 57 (3), 161–165. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18571145 (accessed 12.18.2008).

González–Pérez, O., et al. 2008. [Alpha-tocopherol and alpha-lipoic acid. An antioxidant synergy with potential for preventive medicine.] Rev. Invest. Clin., 60 (1), 58–67. Review. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18589588 (accessed 12.18.2008).

Jia, Z., et al. 2008. Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: Implications for the neuroprotective effects of alpha-lipoic acid. Mol. Cell Biochem. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19082545 (accessed 12.18.2008).

Karakoyun, B., et al. 2008. Alpha-lipoic acid improves acetic acid-induced gastric ulcer healing in rats. Inflammation. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19051000 (accessed 12.18.2008).

Long, J., et al. 2008. Mitochondrial decay in the brains of old rats: Ameliorating effect of alpha-lipoic Acid and acetyl-L-carnitine. Neurochem. Res. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18846423 (accessed 12.18.2008).

Melli, G., et al. 2008. Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. Exp. Neurol., 214 (2), 276–284. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18809400 (accessed 12.18.2008).

Muellenbach, E., et al. 2008. Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker rat. Metabolism, 57 (10), 1465–1472. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18803954 (accessed 12.18.2008).

Park, K., et al. 2008. Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Hepatology, 48 (5), 1477–1486. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18972440 (accessed 12.18.2008).

Petersen Shay, K., et al. 2008. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life, 60 (6), 362–367. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18409172 (accessed 12.18.2008).

Petersen Shay, K., & Hagen, T. 2008. Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A. Biogerontology. [Epub ahead of print.] URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18931933 (accessed 12.18.2008).

Phua, L., et al. 2008. Investigation of the drug-drug interaction between alpha-lipoic acid and valproate via mitochondrial beta-oxidation. Pharm. Res., 25 (11), 2639–2649. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18636319 (accessed 12.18.2008).

Salinthone, S., et al. 2008. Lipoic acid: A novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS. Endocr. Metab. Immune Disord. Drug Targets, 8 (2), 132–142. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18537699 (accessed 12.18.2008).

Shirpoor, A., et al. 2008. Alpha-lipoic acid decreases DNA damage and oxidative stress induced by alcohol in the developing hippocampus and cerebellum of rat. Cell Physiol. Biochem., 22 (5-6), 769–776. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19088458 (accessed 12.18.2008).

Singh, U., & Jialal, I. 2008. Alpha-lipoic acid supplementation and diabetes. Nutr. Rev., 66 (11), 646–657. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19019027 (accessed 12.18.2008).

Vanasco, V., et al. 2008. The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid. Free Radic. Res., 42 (9), 815–823. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19051079 (accessed 12.18.2008).

Holmquist, L., et al. 2007. Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias. Pharmacol Ther., 113 (1), 154–164. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16989905 (accessed 12.18.2008).

Ha, K., et al. 2006. Alpha-lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J. Immunol. 176 (1), 111–117. URL (PDF): http://www.jimmunol.org/cgi/reprint/176/1/111 (accessed 12.18.2008).

Kim, H., et al. 2006. Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Free Radic. Biol. Med., 40 (9), 1483–1493. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16632109 (accessed 12.18.2008).

Prahalathan, C., et al. 2006. Salubrious effects of lipoic acid against adriamycin-induced clastogenesis and apoptosis in Wistar rat bone marrow cells. Toxicology, 222 (3), 225–232. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16580770 (accessed 12.18.2008).

Selvakumar, E., et al. 2006. Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid. Mutat. Res., 606 (1–2), 85–91. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16697249 (accessed 12.18.2008).

Bilska, A., & Włodek, L. 2005. Lipoic acid — the drug of the future? Pharmacol. Rep., 57 (5), 570–577. URL (PDF): http://www.if-pan.krakow.pl/pjp/pdf/2005/5_570.pdf (accessed 12.18.2008).

Byun, C., et al. 2005. Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells. J. Bone Miner. Res., 20 (7), 1125–1135. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15940365 (accessed 12.18.2008).

Koh, J., et al. 2005. Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells. J. Endocrinol., 185 (3), 401–413. URL: http://joe.endocrinology-journals.org/cgi/content/full/185/3/401 (accessed 12.18.2008).

Smith, A., et al. 2004. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr. Med. Chem., 11 (9), 1135–1146. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15134511 (accessed 12.18.2008).

Packer, L., et al. 2001. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition, 17 (10), 888–895. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/11684397 (accessed 12.18.2008).

Packer, L., et al. 1997. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic. Biol. Med., 22 (1–2), 359–378. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/8958163 (accessed 12.18.2008).

Packer, L., et al. 1995. Alpha-lipoic acid as a biological antioxidant. Free Radic. Biol. Med., 19 (2), 227–250. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/7649494 (accessed 12.18.2008).