Better Bones References

Product references — Citrus bioflavonoids

Pang, W. 2010. Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. Br. J. Pharmacol., 159 (8), 1693–1703. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20397301 (accessed 07.01.2010).

Trzeciakiewicz, A., et al. 2010. Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway. J. Nutr. Biochem., 21 (5), 424–431. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19427185 (accessed 07.01.2010).

Trzeciakiewicz, A., et al. 2010. Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation. J. Agric. Food Chem., 58 (1), 668–675. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19921838 (accessed 07.01.2010).

Benavente–García, O., & Castillo, J. 2008. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem., 56 (15), 6185–6205. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18593176 (accessed 12.17.2008).

Imada, K., et al. 2008. Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice. Biochem. Biophys. Res. Commun., 373 (2), 181–185. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18541144 (accessed 12.17.2008).

Kometani, T., et al. 2008. Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans. Immunopharmacol. Immunotoxicol., 30 (1), 117–134. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18306109 (accessed 12.17.2008).

Morin, B., et al. 2008. The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells. J. Nutr., 138 (7), 1274–1281. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18567747 (accessed 12.17.2008).

Zielińska–Przyjemska, M., & Ignatowicz, E. 2008. Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism. Phytother. Res., 22 (12), 1557–1562. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18803250 (accessed 12.17.2008).

Benavente–García, O., et al. 2007. Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways. Cur. Cancer Drug Targets, 7 (8), 795–809. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18220529 (accessed 12.17.2008).

Murakami, A., et al. 2007. Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: Possible involvement of receptor activator of NF-kappaB ligand (RANKL)–induced osteoclastogenesis regulation. Biofactors, 30 (3), 179–192. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18525112 (accessed 12.17.2008).

Cervantes–Laurean, D., et al. 2006. Inhibition of advanced glycation end-product formation on collagen by rutin and its metabolites. J. Nutr. Biochem., 17 (8), 531–540. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16443355 (accessed 12.22.2008).

Kawaguchi, K., et al. 2006. Suppression of collagen-induced arthritis by oral administration of the citrus flavonoid hesperidin. Planta Med., 72 (5), 477–479. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16557465 (accessed 12.17.2008).

Uehara, M. 2006. [Prevention of of osteoporosis by foods and dietary supplements. Hesperidin and bone metabolism.] Clin. Calcium, 16 (10), 1669–1676. Review. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/17012820 (accessed 07.01.2010).

Wong, R., & Rabie, A. 2006. Effect of naringin collagen graft on bone formation. Biomaterials, 27 (9), 1824–1831. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16310246 (accessed 12.17.2008).

Hoensch, H., & Kirch, W. 2005. Potential role of flavonoids in the prevention of intestinal neoplasia: A review of their mode of action and their clinical perspectives. Int. J. Gastrointest. Cancer, 35 (3), 187–195. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/16110120 (accessed 12.17.2008).

Chiba, H., et al. 2003. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J. Nutr., 133 (6), 1892–1897. URL: http://jn.nutrition.org/cgi/content/full/133/6/1892 (accessed 07.01.2010).

Lin, N., et al. 2003. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem. Pharmacol., 65 (12), 2065–2071. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12787887 (accessed 07.01.2010).

Le Marchand, L. 2002. Cancer preventive effects of flavonoids — a review. Biomed. Pharmacother., 56 (6), 296–301. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/12224601 (accessed 12.17.2008).

Ishiwa, J., et al. 2000. A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. J. Rheumatol., 27 (1), 20–25. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/10648013 (accessed 07.01.2010).

Ito, A., et al. 1999. The citrus flavonoid nobiletin suppresses the production and gene expression of matrix metalloproteinases-9/gelatinase B in rabbit synovial cells. Ann. NY Acad. Sci., 878, 632–634. URL (no abstract available): http://www.ncbi.nlm.nih.gov/pubmed/10415793 (accessed 07.01.2010).

Guthrie, N., & Carroll, K. 1998. Inhibition of mammary cancer by citrus flavonoids. Adv. Exp. Med. Biol., 439, 227–236. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/9781306 (accessed 12.17.2008).

So, F., et al. 1996. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr. Cancer, 26 (2), 167–181. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/8875554 (accessed 12.17.2008).