Our Serinisol is doctor-formulated to be complete, natural, bioavailable, and manufactured to pharmaceutical standards.
The following articles and studies, arranged in order of recency, represent a sampling of the research on the constituents of Serinisol.
L-theanine . Monograph. Altern Med Rev. 2005 Jun;10(2):136-8. PubMed PMID: 15989383.
Borzelleca JF, Peters D, Hall W. A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats. Food Chem Toxicol. 2006 Jul;44(7):1158-66. Epub 2006 Apr 26. PubMed PMID: 16759779.
Bryan J. Psychological effects of dietary components of tea: caffeine and L-theanine. Nutr Rev. 2008 Feb;66(2):82-90. doi: 10.1111/j.1753-4887.2007.00011.x. Review. PubMed PMID: 18254874.
Cho HS, Kim S, Lee SY, Park JA, Kim SJ, Chun HS. Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology. 2008 Jul;29(4):656-62. doi: 10.1016/j.neuro.2008.03.004. Epub 2008 Mar 20. PubMed PMID: 18452993.
Desai MJ, Armstrong DW. Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(3):251-6. PubMed PMID: 14755608.
Egashira N, Hayakawa K, Mishima K, Kimura H, Iwasaki K, Fujiwara M. Neuroprotective effect of gamma-glutamylethylamide (theanine) on cerebral infarction in mice. Neurosci Lett. 2004 Jun 3;363(1):58-61. PubMed PMID: 15157996.
Eschenauer G, Sweet BV. Pharmacology and therapeutic uses of theanine. Am J Health Syst Pharm. 2006 Jan 1;63(1):26, 28-30. PubMed PMID: 16373462.
Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009 Jun;22(1):44-51. doi: 10.1007/s10548-008-0068-z. Epub 2008 Oct 9. PubMed PMID: 18841456.
Gomez-Ramirez M, Higgins BA, Rycroft JA, Owen GN, Mahoney J, Shpaner M, Foxe JJ. The deployment of intersensory selective attention: a high-density electrical mapping study of the effects of theanine. Clin Neuropharmacol. 2007 Jan-Feb;30(1):25-38. PubMed PMID: 17272967.
Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. 2008 Feb;77(2):113-22. Epub 2007 Sep 26. PubMed PMID: 18006208.
Jang HS, Jung JY, Jang IS, Jang KH, Kim SH, Ha JH, Suk K, Lee MG. L-theanine partially counteracts caffeine-induced sleep disturbances in rats. Pharmacol Biochem Behav. 2012 Apr;101(2):217-21. doi: 10.1016/j.pbb.2012.01.011. Epub 2012 Jan 21. PubMed PMID: 22285321.
Kakuda T, Nozawa A, Unno T, Okamura N, Okai O. Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat. Biosci Biotechnol Biochem. 2000 Feb;64(2):287-93. PubMed PMID: 10737183.
Kakuda T, Hinoi E, Abe A, Nozawa A, Ogura M, Yoneda Y. Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain. J Neurosci Res. 2008 Jun;86(8):1846-56. doi: 10.1002/jnr.21637. PubMed PMID: 18293419.
Kim TI, Lee YK, Park SG, Choi IS, Ban JO, Park HK, Nam SY, Yun YW, Han SB, Oh KW, Hong JT. l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways. Free Radic Biol Med. 2009 Dec 1;47(11):1601-10. doi: 10.1016/j.freeradbiomed.2009.09.008. Epub 2009 Sep 16. PubMed PMID: 19766184.
Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45. Epub 2006 Aug 22. PubMed PMID: 16930802.
Lu K, Gray MA, Oliver C, Liley DT, Harrison BJ, Bartholomeusz CF, Phan KL, Nathan PJ. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol. 2004 Oct;19(7):457-65. PubMed PMID: 15378679.
Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011 Dec;16(4):348-54. PubMed PMID: 22214254.
Matsumoto K, Yamada H, Takuma N, Niino H, Sagesaka YM. Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial. BMC Complement Altern Med. 2011 Feb 21;11:15. doi: 10.1186/1472-6882-11-15. PubMed PMID: 21338496; PubMed Central PMCID: PMC3049752.Free full text
Nagasawa K, Aoki H, Yasuda E, Nagai K, Shimohama S, Fujimoto S. Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochem Biophys Res Commun. 2004 Jul 16;320(1):116-22. PubMed PMID: 15207710.
Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30. Review. PubMed PMID: 17182482.
Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PubMed PMID: 18296328.
Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SS. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food. 2011 Apr;14(4):334-43. doi: 10.1089/jmf.2009.1374. Epub 2011 Feb 8. PubMed PMID: 21303262.
Ritsner MS, Miodownik C, Ratner Y, Shleifer T, Mar M, Pintov L, Lerner V. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry. 2011 Jan;72(1):34-42. doi: 10.4088/JCP.09m05324gre. Epub 2010 Nov 30. PubMed PMID: 21208586.
Rogers PJ, Smith JE, Heatherley SV, Pleydell-Pearce CW. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology (Berl). 2008 Jan;195(4):569-77. Epub 2007 Sep 23. PubMed PMID: 17891480.
Tian X, Sun L, Gou L, Ling X, Feng Y, Wang L, Yin X, Liu Y. Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain Res. 2013 Mar 29;1503:24-32. doi: 10.1016/j.brainres.2013.01.048. Epub 2013 Feb 5. PubMed PMID: 23395732.
Unno K, Tanida N, Ishii N, Yamamoto H, Iguchi K, Hoshino M, Takeda A, Ozawa H, Ohkubo T, Juneja LR, Yamada H. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary a-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav. 2013 Oct;111:128-35. doi: 10.1016/j.pbb.2013.09.004. Epub 2013 Sep 16. PubMed PMID: 24051231.
Wise LE, Premaratne ID, Gamage TF, Lichtman AH, Hughes LD, Harris LS, Aceto MD. l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice. Pharmacol Biochem Behav. 2012 Dec;103(2):245-52. doi: 10.1016/j.pbb.2012.08.008. Epub 2012 Aug 23. PubMed PMID: 22935630; PubMed Central PMCID: PMC3754842.
Yin C, Gou L, Liu Y, Yin X, Zhang L, Jia G, Zhuang X. Antidepressant-like effects of L-theanine in the forced swim and tail suspension tests in mice. Phytother Res. 2011 Nov;25(11):1636-9. doi: 10.1002/ptr.3456. Epub 2011 Mar 21. PubMed PMID: 21425373.
Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res. 1998 May;23(5):667-73. PubMed PMID: 9566605.
Yokogoshi H, Terashima T. Effect of theanine, r-glutamylethylamide, on brain monoamines, striatal dopamine release and some kinds of behavior in rats. Nutrition. 2000 Sep;16(9):776-7. PubMed PMID: 10978861.
Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012 Oct 29;31:28. doi: 10.1186/1880-6805-31-28. PubMed PMID: 23107346; PubMed Central PMCID: PMC3518171.Free full text
Zukhurova M, Prosvirnina M, Daineko A, Simanenkova A, Petrishchev N, Sonin D, Galagudza M, Shamtsyan M, Juneja LR, Vlasov T. L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. Phytother Res. 2013 Sep;27(9):1282-7. doi: 10.1002/ptr.4868. Epub 2012 Oct 24. PubMed PMID: 23097345.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to L-theanine from Camellia sinensis (L.) Kuntze (tea) and improvement of cognitive function (ID 1104, 1222, 1600, 1601, 1707, 1935, 2004, 2005), alleviation of psychological stress (ID 1598, 1601), maintenance of normal sleep (ID 1222, 1737, 2004) and reduction of menstrual discomfort (ID 1599) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2011;9(6):2238. [23 pp.]. doi:10.2903/j.efsa.2011.2238. Available online: www.efsa.europa.eu/efsajournal
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Carroll, D., et al. 2000. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: A double-blind placebo-controlled trial. Psychopharmacology (Berl.), 150 (2), 220–225. URL (abstract/intro): http://www.springerlink.com/content/6vg3yg6k93rakn17/ (accessed 01.28.2011).
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Garalejic, E., et al. 2010. Hamilton anxiety scale (HAMA) in infertile women with endometriosis and its correlation with magnesium levels in peritoneal fluid. Psychiatr. Danub., 22 (1), 64–67. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/20305593 (accessed 02.09.2011).
Jung, K., et al. 2010. Associations of serum Ca and Mg levels with mental health in adult women without psychiatric disorders. Biol. Trace Elem. Res., 133 (2), 153–161. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/19543697 (accessed 02.09.2011).
Lakhan, S., & Vieira, K. 2010. Nutritional and herbal supplements for anxiety and anxiety-related disorders: Systematic review. Nutr. J., 9 (1), 42. URL: http://www.nutritionj.com/content/9/1/42 (accessed 01.28.2011).
Nielsen, F., et al. 2010. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes. Res., 23 (4), 158–168. URL: http://www.ncbi.nlm.nih.gov/pubmed/21199787 (accessed 02.09.2011).
Jacka, F., et al. 2009. Association between magnesium intake and depression and anxiety in community-dwelling adults: The Hordaland Health Study. Aust. NZ J. Psychiatry, 43 (1), 45–52. URL (abstract):http://www.ncbi.nlm.nih.gov/pubmed/19085527 (accessed 02.09.2011).
Muroyama, A., et al. 2009. Enhanced susceptibility to MPTP neurotoxicity in magnesium-deficient C57BL/6N mice. Neurosci. Res., 63 (1), 72–75. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18977253 (accessed 02.09.2011).
Poleszak, E. 2008. Benzodiazepine/GABA(A) receptors are involved in magnesium-induced anxiolytic-like behavior in mice. Pharmacol. Rep., 60 (4), 483–489. URL (PDF): http://www.if-pan.krakow.pl/pjp/pdf/2008/4_483.pdf (accessed 02.09.2011).
Poleszak, E., et al. 2008. NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice. Pharmacol. Rep., 60 (5), 655–663. URL (PDF): http://www.if-pan.krakow.pl/pjp/pdf/2008/5_655.pdf (accessed 02.09.2011).
Spasov, A., et al. 2008. [Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet]. Zh. Vyssh. Nerv. Deiat Im. IP Pavlova, 58 (4), 476–485. Russian. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/18825946 (accessed 02.09.2011).
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Durlach, J., et al. 2004. Importance of magnesium depletion with hypofunction of the biological clock in the pathophysiology of headaches with photophobia, sudden infant death and some clinical forms of multiple sclerosis. Magnes. Res., 17 (4), 314–326. URL (abstract): http://www.ncbi.nlm.nih.gov/pubmed/15726907 (accessed 02.09.2011).
Fromm, L., et al. 2004. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. J. Am. Coll. Nutr., 23 (5), 529S–533S. URL: http://www.jacn.org/cgi/reprint/23/5/529S (accessed 01.28.2011).
Hanus, M., et al. 2004. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr. Med. Res. Opin., 20 (1), 63–71. URL (abstract): http://informahealthcare.com/doi/abs/10.1185/030079903125002603 (accessed 01.28.2011).
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