Our L-Glutamine is a safe, natural digestive GI support formula manufactured to pharmaceutical standards.

The following articles and studies, arranged alphabetically, represent a sampling of the research on L-glutamine.

Ban, K. and Kozar, R. A. 2010. Glutamine protects against apoptosis via down regulation of Sp3 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 399(6): G1344-G1353. doi: 10.1152/ajpgi.00334.2010. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006244/?tool=pmcentrez (accessed 5/7/2012).

Candow, D. G., et al. 2001. Effect of glutamine supplementation combined with resistance training in young adults. Eur J Appl Physiol., 86(2): 142-9. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/11822473?dopt=Abstract (Accessed 5/9/2012).

Chen, G., et al. 2001. [Clinical observation of the protective effect of oral feeding of glutamine granules on intestinal mucous membrane.] Zhonghua Shao Shang Za Zhi., 17(4):2010.1. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/11876941?dopt=Abstract (accessed 5/9/2012).

Coëffier, M., et al. 2005. Effect of glutamine on water and sodium absorption in human jejunum at baseline and during PGE1-induced secretion. J Appl Physiol. 98(6): 2163-8. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/15661841?dopt=Abstract (accessed 5/9/2012).

Coëffier, M., et al. 2003. Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa. Am J Physiol Gastrointest Liver Physiol. 285(2): G266-73. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/12702496?dopt=Abstract (accessed 5/9/2012).

Dai, Z. L., et al. 2012. L-Glutamine regulates amino acid utilization by intestinal bacteria. Amino Acids., 2012 Mar 24 Epub. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/22451274 (accessed 5/8/2012).

Hond, D. E., et al. 1999. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn’s disease. JPEN J Parenter Enteral Nutr., 23(1): 7-11. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/9888411.1 (accessed 5/9/2012).

Jian, Z. M., et al. 1999. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr., 26(5 Suppl): S62-6. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/10483898?dopt=Abstract (accessed 5/9/2012).

Kennedy, D., et al. 2007. Cost Effectiveness of Natural Health Products: A Systematic Review of Randomized Clinical Trials. Evid Based Complement Alternat Med., 6(3): 297-304. doi: 10.1093/ecam/nem167. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722206/?tool=pmcentrez (accessed 5/7/2012).

Larson, S., et al. 2007. Molecular Mechanisms Contributing to Glutamine-Mediated Intestinal Cell Survival. Am J Physiol Gastrointest Liver Physiol., 293(6): G1262 – G1271. doi: 10.1152/ajpgi.00254.2007. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432018/?tool=pmcentrez (accessed 5/7/2012).

May, P. E., et al. 2002. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-mehtylbutyrate, arginine, and glutamine. Am J Surg., 183(4): 471-9. URl (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/11975938?dopt=Abstract (accessed 5/9/2012).

Mok, E. and Hankard, R. 2011. Glutamine Supplementation in Sick Children: Is It Beneficial? J Nutr Metab. 2001: 617597. doi: 10.1155/2011/617597. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228321/?tool=pmcentrez (accessed 5/7/2012).

Motoki, T., et al. 2011. Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium. World J Gastroenterol., 17(6): 717-726. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042649/?tool=pmcentrez (accessed 5/7/2012).

Niihara, Y., et al. 2005. L-Glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells. BMC Blood Disord., 5:4. doi: 10.1186/1471-2326-5-4. URL (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1198219/?tool=pmcentrez (accessed 5/8/2012).

Nose, K., et al. 2010. Glutamine Prevents Total Parenteral Nutrition-Associated Changes to Intraepithelial Lymphocyte Phenotype and Function: A Potential Mechanism for the Preservation of Epithelial Barrier Function. J Interferon Cytokine Res., 30(2): 67-79. doi: 10.1089/jir.2009.0046. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830305/?tool=pmcentrez (accessed 5/7/2012).

Noyer, C. M., et al. 1998. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol., 93(6): 972-5. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/9647031?dopt=Abstract (accessed 5/9/2012).

Sakiyama, T., et al. 2009. Glutamine increases autophagy under basal and stressed conditions in intestinal epithelial cells. Gastroenterology. 136(3): 924-932. doi: 10.1053/j.gastro.2008.12.002. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673957/?tool=pmcentrez (accessed 5/7/2012).

Van Der Hulst, R. R., et al. 1997. Glutamine and intestinal immune cells in humans. JPEN J Parenter Enteral Nutr., 21(6): 310-5. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/9406126?dopt=Abstract (accessed 5/9/2012).

Van Der Hulst, R. R., et al. 1996. The effect of glutamine administration on intestinal glutamine content. J Surg Res., 61(1): 30-4. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/8769938?dopt=Abstract (accessed 5/9/2012)/

Van Der Hulst, R. R., et al. 1993. Glutamine and the preservation of gut integrity. Lancet, 341(8857): 1363-5. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/8098788?dopt=Abstract (accessed 5/9/2012).

Yalçin, S. S., et al. 2004. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J Pedatr Gastroenterol Nutr., 38(5):494-51. URL (abstract only): http://www.ncbi.nlm.nih.gov/pubmed/15097437?dopt=Abstract (accessed 5/9/2012).