Women’s Health Network Melatonin is doctor-formulated to be complete, natural, bioavailable and manufactured to pharmaceutical standards.

The following articles and studies, arranged alphabetically, represent a sampling of the research on the melatonin.

Alvarez B., et al. 1992. The delayed sleep phase syndrome: Clinical and investigative findings in 14 patients. J Neurol Neurosurg Psychiatry.55:665-670. URL (abstract only): (accessed 07/10/2013).

Appleton, R. E., & Gringras, P. 2013. Melatonin: helping to MEND impaired sleep. Arch Dis Child. 98:216-217. URL (abstract only): (accessed 07/10/2013).

Armstrong, S.M. & Redman, J.R. 1991. Melatonin: A chronobiotic with anti-aging properties? Med Hypotheses. 34:300-309. URL (abstract only): (accessed 07/10/2013).

Beck-Friis J., et al. 1985. Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand.71:319-330. URL (abstract only): (accessed 07/10/2013).

Bismar, K., et al. 1987. Depressed melatonin secretion in patients with nightmares due to beta adrenoceptor blocking drug. Acta Med Scand. 221:155-158. URL (abstract only): (accessed 07/10/2013).

Brown, G.M., et al. 2009. Melatonin and its relevance to jet lag. Travel Med Infect is. 7(2): 69-81. URL (abstract only): (accessed 07/10/2013).

Cardinali, D.P., et al. 2011. The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer’s disease. Recent Pat Endocr Metab Immune Drug Discov. 5(2): 80-90. URL (abstract only): (accessed 07/10/2013).

Carpentieri, A., et al. 2012. New perspectives in melatonin uses. Pharmacol Res. 65(4): 437-44. URL (abstract only): (accessed 07/10/2013).

Comperatore, C. A., et al. 1996. Melatonin efficacy in aviation missions requiring repaid deployment and night operations. Aviat Space Environ Med. 67(6):520-4. URL (abstract only): (accessed 07/10/2013).

Dahlitz, M., et al. 1991. Delayed sleep phase syndrome response to melatonin. Lancet. 337:1121-1124. URL (abstract only): (accessed 07/10/2013).

Dawson, D. & Armstrong, S.M. 1996. Chronobiotics – drugs that shift rhythms. Pharmacol Ther. 69 (1): 15-36. URL (abstract only): (accessed 07/10/2013).

Dijk, D. J., et al. 2012. Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS One. 7(2):e30037. URL (abstract only): (accessed 07/10/2013).

Eckerberg, B., et al. 2012. Melatonin treatment effects on adolescent students’ sleep timing and sleepiness in a placebo-controlled crossover study. Chronobiol Int. 29(9): 1239-48. URL (abstract only): (accessed 07/10/2013).

Elbaz, I., et al. 2013. Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish. Front Neural Circuits. Epub February 1, 2013. URL: (accessed 06/13/2013).

Gorfine, T., et al. 2006. S;eep-anticipating effects of melatonin in the human brain. Neuroimage. 31(1): 410-8. URL (abstract only): (accessed 07/10/2013).

Jan, J.E. & Freeman, R.D. 2007. Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade? Developmental Medicine & Child Neurology. 46(11): 776-782. URL (abstract only): (accessed 07/10/2013).

Jarratt, J. 2011. Perioperative melatonin use. Anaesth Intensive Care. 39(2): 171-81. URL (abstract only): (accessed 07/10/2013).

Lieberman, H.R. 1989. Behavior, sleep and melatonin. J Neural Transm Suppl. 21:233-241. URL (abstract only): (accessed 07/10/2013).

Lieberman, H.R., et al. 1985. Possible behavioral consequences of light-induced changes in melatonin availability. Ann N Y Acad Sci. 453: 242-52. URL (abstract only): (accessed 07/10/2013).

Lieberman, H.R., et al. 1984. Effects of melatonin on human mood and performance. Brain Res. 323(2): 201-7. URL (abstract only): (accessed 07/10/2013).

Lissoni, P., et al. 1992. Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first-line chemotherapy containing cisplatin. Oncology. 49(5): 336-9. URL (abstract only): (accessed 07/10/2013).

Lissoni, P., et al. 1991. Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Oncology. 48:448-450. URL (abstract only): (accessed 07/10/2013).

Lissoni, P., et al. 1989. Endocrine and immune effects of melatonin therapy in metastatic cancer patients. Eur J Cancer Clin Oncol. 25(5): 789-95. URL (abstract only): (accessed 07/10/2013).

Lyseng-Williamson, K.A. 2012. Melatonin prolonged release: in the treatment of insomnia in patients aged =55 years. Drugs Aging. 29(11): 911-23. ULR (abstract only): (accessed 07/10/2013).

Paul, M.A., et al. 2011. Phase advance with separate and combined melatonin and light treatment. Psychopharmacology (Berl.). 214(2): 515-23. URL (abstract only): (accessed 07/10/2013).

Paul, M.A., et al. 2010. Melatonin treatment for eastward and westward travel preparation. Psychopharacology (Berl). 208(3): 377-86. URL (abstract only): (accessed 07/10/2013).

Petterborg, L. J., et al. 1991. Effect of melatonin replacement on serum hormone rhythms in a patient lacking endogenous melatonin. Brain Res Bull. 27(2): 181-5. URL (abstract only): (accessed 07/10/2013).

Radeljak, S., et al. 2008. Chromotherapy in the regulation of neurohormonal balance in human brain – complementary application in modern psychiatric treatment. Coll Antropol. 32 Suppl 2: 185-8. URL (abstract only): (accessed 07/10/2013).

Reiter, R.J. & Korkmaz, A. 2008. Clinical aspects of melatonin. Saudi Med J.29(11): 1537-47. URL (abstract only): (accessed 07/10/2013).

Rios, E.R., et al. 2012. Melatonin: pharmacological aspects and clinical trends. Int J Neurosci. 120(9): 583-90. URL (abstract only): (accessed 07/10/2013).

Scheer, F.A., et al. 2012. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 35(10): 1395-402. URL (abstract only): (accessed 07/10/2013).

Srinivasan, V., et al. 2009. Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci. URL (abstract only): (accessed 07/10/2013).

Turek, F.W. & Gillette, M.U. 2004. Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep Med. 5(6): 523-32. URL (abstract only): (accessed 07/10/2013).

Waldhauser, F., et al. 1987. A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisol. Neuroendocrinology. 46(2): 125-30. URL (abstract only): (accessed 07/10/2013).

Waldhauser, F., et al. 1984. Bioavailability of oral melatonin in humans. Neuroendocrinology. 39(4): 307-13. URL (abstract): (accessed 07/10/2013).

Wyatt, J.K., et al. 2006. Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep. 29(5): 609-18. URL (abstract only): (accessed 07/10/2013).

Zawilska, J.B., et al. 2009. Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacol Rep. 61(3): 383-410. URL (abstract only): (accessed 07/10/2013).